NAD: The Supercentenarian Molecule
Dec 18 , 2020

NAD: The Supercentenarian Molecule

Over 100 years ago the co-enzyme nicotinamide adenine dinucleotide (NAD) was discovered. Called a “supercentenarian” molecule (Chini, 2017), it is of tremendous interest to longevity researchers and enthusiasts.
BioViva's AgingSOS™ test evaluates your NAD levels. 
Every cell of every living thing contains NAD. It carries out important functions in the body that are vital for general health. NAD is needed to catalyze reactions for over 400 enzymes, more than any other vitamin-derived coenzyme. Its essential role for life and health spans everything from repairing DNA damage to energy (ATP) production. 
Multiple studies have discovered that NAD levels diminish with time. This decrease plays a role in the development of many age-related maladies like Alzheimer’s, obesity, and even various cancers.
It has been found that supplementing with NAD precursors replenishes declining NAD levels, and thereby potentially mitigating age-related decline. Furthermore, studies have discovered that both genetic and nutritional activation of NAD can contribute to life extension in a diverse array of model organisms.
NAD levels change during many physiological processes. Mounting evidence indicates that intracellular NAD levels are significantly affected by nutritional and environmental stimuli. 
These changes in NAD content are reflected in NAD-dependent enzymatic activities, which in turn lead to changes in cellular metabolism, gene expression, and protein function. Therefore, maintenance of a proper intracellular NAD concentration appears critical to maintain tissue 
One explanation for the loss of NAD is that one or more of the NAD-biosynthetic pathways, such as the NAMPT pathway, decline. NAMPT is an important regulator of the intracellular NAD pool. Through its NAD-biosynthetic activity, NAMPT influences the activity of NAD-dependent enzymes, such as SIRTUINS and PARPs, and thereby regulates cellular metabolism, mitochondrial biogenesis, and responses to inflammatory, oxidative, proteotoxic, and genotoxic stress.
With all of this in mind, it is critical for us to determine the NAD we have in our bodies, so we may best circumvent the debilitating problems associated with lower NAD levels. AgingSOS™ is a blood test that identifies NAD levels and targets your aging to empower you to make decisions that most benefit your health.
All of the biomarkers targeted (including NAD) are actionable, meaning they can be altered by lifestyle interventions or supplementation. 
The key to this test is that it will guide you to better health by showing you where your body needs your attention most. For example, chronic inflammation is a driver of aging that can lead to cancer. If you can identify and end chronic inflammation before symptoms show up, you will reduce your risk of inflammation-mediated diseases like heart disease or diabetes.
With AgingSOS™ you can better understand what must be done to better ensure a longer, healthier life, free from debilitating and preventable terminal diseases.


References and Suggested Reading
Katsyuba, E. & Auwerx, J. Modulating NAD(+) metabolism, from bench to bedside. EMBO J 36, 2670–2683, (2017).
Yaku, K., Okabe, K. & Nakagawa, T. NAD metabolism: Implications in aging and longevity. Ageing Res Rev 47, 1–17, (2018).
Yoshino, J., Baur, J. A. & Imai, S. I. NAD(+) Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab 27, 513–528, (2018).

Adam Alonzi

Adam Alonzi is a writer, biotechnologist, documentary maker, futurist, inventor, programmer, and author two novels. He is an analyst for the Millennium Project, and Head of Social Media and Content Creation for BioViva Sciences. Listen to his podcasts here. Read his blog here.